| Title: | Association between chronic fatigue and common cerebrovascular and neurodegenerative diseases: a prospective cohort study |
| Journal: | Fatigue Biomedicine Health & Behavior |
| Published: | 16 Jun 2026 |
| DOI: | https://doi.org/10.1080/21641846.2026.2667698 |
Publication 20622
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Abstract
Chronic fatigue (CF) is increasingly prevalent, yet its role as an independent risk factor for cerebrovascular and neurodegenerative diseases remains underexplored. This study aimed to prospectively assess the association between CF and the risks of Parkinson's disease (PD), Alzheimer's disease (AD), cerebral infarction (CI), and all-cause mortality (ACM). We utilized data from 167,098 UK Biobank participants (aged 40-69) with baseline information on CF (≥6 months). Cox proportional hazards models with three tiers of covariate adjustment (demographics, lifestyle, comorbidities) were used to examine associations with incident PD, AD, CI, and ACM. Fine-Gray competing risk models accounting for death were also employed for PD, AD, and CI. CF was independently associated with significantly increased risks of PD (fully-adjusted HR = 3.02, 95% CI = 2.42-3.76, p < 0.0001), AD (HR = 1.68, 1.21-2.34, p = 0.002), CI (HR = 1.19, 1.02-1.39, p = 0.027), and ACM (HR = 1.86, 1.73-2.00, p < 0.0001). Competing risk analyses confirmed robustness (e.g. for PD: sHR = 2.97, p < 0.0001). Chronic fatigue is an independent risk factor for developing PD, AD, CI, and for ACM. Assessment of CF may help identify high-risk populations for targeted prevention.</p>
11 Authors
- Jiang Xu
- Daihai Mo
- Yang Cai
- Hongyao Lv
- Minjing Wei
- Yue Zhang
- Fengyang Jing
- Wenhui Wu
- Xiaoyu Fang
- Yanzhou Wang
- Xiangyu Ma
1 Application
| Application ID | Title |
|---|---|
| 657275 | The influence of lifestyle, social factors, psychological status, COVID-19 condition, environmental and genetic factors on major non-communicable diseases and the mediating role of plasma biomarkers |
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