| Title: | A genome-wide association study of stroke risk in Asian statin users: evidence from KoGES and UK Biobank |
| Journal: | Pharmacogenomics |
| Published: | 13 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40948399/ |
| DOI: | https://doi.org/10.1080/14622416.2025.2558499 |
Publication 19743
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Abstract
BACKGROUND: Despite proven efficacy of statins in stroke prevention, genetic factors may influence individual stroke risk among statin users. With increasing precision medicine approaches and growing evidence of population-specific genetic variations, identifying genetic markers that predict stroke risk in statin-treated Asian populations has become critically important for personalized cardiovascular prevention strategies.</p>
METHODS: We conducted a genome-wide association study of 1,678 participants using lipid-lowering agents in the Korean Genome and Epidemiology Study (KoGES) cohort. Significant findings were replicated in 2,170 Asian participants on statins from the UK Biobank using an additive genetic model adjusted for relevant covariates.</p>
RESULTS: In the discovery analysis, 83 single nucleotide polymorphisms were suggestively associated with stroke (p <1.0 × 10-5). Among these, 21 SNPs in the CDH13 gene were associated with increased stroke risk. The lead SNP, rs7201829, was significantly replicated in the UK Biobank (odds ratio: 2.29, p = 2.39 × 10-5).</p>
CONCLUSIONS: This study identified CDH13 as a significant genetic marker associated with stroke risk among Asian statin users. These findings provide the first genome-wide evidence for genetic determinants of stroke susceptibility during statin therapy, supporting the development of personalized prevention strategies in Asian populations.</p>
18 Keywords
- Aged
- Asian People
- Biological Specimen Banks
- Cadherins
- Cohort Studies
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Republic of Korea
- Risk Factors
- Stroke
- UK Biobank
- United Kingdom
7 Authors
- Da Hoon Lee
- Yoon-A Park
- Jung Sun Kim
- Yubin Song
- SeungJin Bae
- Jeong Yee
- Hye Sun Gwak
1 Application
| Application ID | Title |
|---|---|
| 126305 | Risk scoring system development of statin adverse events and resistance using clinical and genetic factors for individualized pharmaceutical care service |
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