| Title: | More than step counts: Slow walking speed, limited running, and fewer long walks predict cardiovascular mortality in the Walk Watch UK Biobank study |
| Journal: | The Journals of Gerontology Series A |
| Published: | 22 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40845147/ |
| DOI: | https://doi.org/10.1093/gerona/glaf184 |
Publication 19700
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Abstract
BACKGROUND: Low daily step counts have traditionally been associated with cardiovascular death risk, suggesting other objective real-world gait measures may be complementary or better predictors. This study examined the relationship between real-world walking speed, quality, and walking bout distributions, measured using a wrist-worn device, and cardiovascular death in a large cohort of older people.</p>
METHODS: Participants aged 60 to 78 years from the UK Biobank who wore a wrist-worn device were included in this population-based observational cohort study. Gait data were analyzed using Watch Walk methods. Cardiovascular death, defined as death within nine years of follow-up due to heart disease, stroke, or vascular conditions, was tracked using National Health Service databases. Minimally adjusted and multivariable Cox proportional-hazard models assessed the relationship between digital gait biomarkers and cardiovascular death.</p>
RESULTS: Among 38 766 participants, 485 (1.3%) had cardiovascular deaths during follow-up. In minimally adjusted models, maximal walking speed, running duration, step count, longest walk duration, and the proportion of short walks were associated with cardiovascular death. In multivariable models adjusted for age, sex and smoking status, slower maximal walking speed, reduced daily running duration, and a higher proportion of short walks remained independent predictors. This model had a C-statistic of 0.75, comparable to traditional risk scores including SCORE2 and the Framingham Risk Score (both 0.74).</p>
CONCLUSIONS: Walking speed, running duration, and the proportion of longer walks are key real-world walking characteristics to consider when assessing cardiovascular death risk. Predictive models with these measures demonstrate good accuracy, suggesting a noninvasive option for early risk assessment.</p>
14 Keywords
- Aged
- Biological Specimen Banks
- Cardiovascular Diseases
- Female
- Humans
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Running
- UK Biobank
- United Kingdom
- Walking
- Walking Speed
5 Authors
- Beatriz Herrero Pinilla
- Serena Hong
- Matthew A Brodie
- Stephen R Lord
- Lloyd L Y Chan
1 Application
| Application ID | Title |
|---|---|
| 103840 | Investigating the pathophysiological mechanism and genetic basis of gait pattern changes in older adults |
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