| Title: | Contrasting associations of blood lipids with risk of myocardial infarction in Chinese and European adults |
| Journal: | European Heart Journal Open |
| Published: | 29 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41079004/ |
| DOI: | https://doi.org/10.1093/ehjopen/oeaf119 |
| URL: | https://academic.oup.com/ehjopen/advance-article-pdf/doi/10.1093/ehjopen/oeaf119/64324861/oeaf119.pdf |
Publication 19631
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Aims: Little is known about the importance of blood lipids for risk of myocardial infarction (MI) in Chinese vs. European populations. We compared the associations with MI of apolioprotein B (ApoB) vs. low-density lipoprotein cholesterol (LDL-C) and remnant-cholesterol (remnant-C) vs. triglycerides in the China Kadoorie Biobank (CKB) and UK Biobank (UKB).</p>
Methods and results: Plasma levels of LDL-C, high-density lipoprotein-cholesterol (HDL-C), apolipoprotein B (ApoB), apolipoprotein A1 (ApoA1), non-HDL-C, remnant-C, LDL-C/ApoB, and HDL-C/ApoA1 ratios were measured in a nested case-control study of MI (948 cases, 6101 controls) in CKB and a prospective study (5344 cases in 279 989 participants) in UKB. Associations of lipids with MI were assessed using logistic regression in CKB and Cox regression in UKB after adjustment for confounders and correction for regression dilution. The mean levels of LDL-C were about 30% lower in CKB than in UKB [2.3 (0.6) vs. 3.7 (0.8) mmol/L], but mean levels of HDL-C were comparable [1.3 (0.3) vs. 1.5 (0.4) mmol/L], as were those for triglycerides [1.8 (1.1) vs. 1.7 (1.1) mmol/L]. While the rate ratios (RRs) of MI for 1 SD higher usual levels of LDL-C in Chinese were about half those in Europeans (1.27; 1.13-1.44 vs. 1.55; 1.49-1.61), the corresponding RRs for ApoB or non-HDL with MI were comparable between Chinese and Europeans.</p>
Conclusion: The findings reinforce current guidelines for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in China that advocate initiation of statin treatment in individuals at high-risk of ASCVD rather than high levels of LDL-C.</p>
15 Authors
- Hanyu Wang
- Robert Clarke
- Christiana Kartsonaki
- Iona Millwood
- Robin Walters
- Michael Hill
- Daniel Avery
- Canqing Yu
- DianJian-Yi Sun
- Jun Lv
- Shanpeng Li
- Liming Li
- Zhengming Chen
- Neil Wright
- Derrick A Bennett
1 Application
| Application ID | Title |
|---|---|
| 50474 | Multi-trait trans-ethnic genetic analyses |
Enabling scientific discoveries that improve human health