| Title: | Serum 25 (OH) D levels and risk of female-specific cancer in premenopausal women: a prospective study |
| Journal: | Frontiers in Nutrition |
| Published: | 15 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41031356/ |
| DOI: | https://doi.org/10.3389/fnut.2025.1617565 |
| URL: | https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2025.1617565/pdf |
Publication 19496
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Abstract
Background: Serum 25 (OH) D levels are associated with various diseases, including cancers, but inconsistencies exist for female-specific malignancies. This study is aimed to explore the real relationship between serum 25 (OH) D levels and incidence rates of female specific cancers in premenopausal women by a large-scale prospective cohort study.</p>
Study design: We analyzed data from 51,286 UK Biobank participants using Cox regression models to explore associations. Subgroup analyses were based on vitamin D supplementation, alcohol, smoking, BMI, diabetes, sleep, and outdoor exposure. Categorical variables were described by frequencies and compared with chi-squared tests.</p>
Results: During a median follow-up of 13.8 years, all cancer incidence was 5.1% (n = 2,614), with ovarian cancer at 0.3% (n = 176), breast cancer at 4.4% (n = 2,232), and uterine body cancer at 0.5% (n = 235). Low serum 25 (OH) D (50 nmol/L) was linked to increased risks of ovarian (HR: 1.457, 95% CI: 1.047-2.027) and uterine body cancer (HR: 1.372, 95% CI: 1.023-1.841). Each 10 nmol/L increase in 25 (OH) D reduced ovarian cancer risk (HR: 0.904, 95% CI: 0.835-0.979). Alcohol use and sleep <6 h were risk factors for ovarian and uterine cancer in those with low 25 (OH) D levels.</p>
Conclusion: Maintaining adequate serum 25 (OH) D levels is essential for overall health, reducing the risk of ovarian cancer, and potentially lowering susceptibility to uterine corpus cancer.</p>
7 Authors
- Yue Hu
- Chen Zhu
- Yingyi Qin
- Ying Zhu
- Jianzheng Zhang
- Qiang Tong
- Shengyun Cai
1 Application
| Application ID | Title |
|---|---|
| 106397 | Analysis of risk factors for hematopoietic and immune system aging and their association with immune diseases and cancer |
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