| Title: | Long-term exposure to low-level nitrogen dioxide and risks of neurodegenerative diseases among middle-aged and older adults in the UK |
| Journal: | Environmental Science Processes & Impacts |
| Published: | 17 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40856181/ |
| DOI: | https://doi.org/10.1039/d5em00342c |
Publication 19483
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Abstract
Divergent views remain regarding the health assessment of ambient nitrogen dioxide (NO2) exposure at low-level concentrations. To fill in some gaps, this study was designed to comprehensively estimate the effects of low-level NO2 exposure on the brain system. This study included 183 351 participants with ambient NO2 ≤ 20 μg m-3 at baseline from the UK Biobank and analyzed associations of NO2 exposure with neurodegenerative diseases and brain imaging traits through modeling. The results indicated that among populations exposed to ambient NO2 ≤ 20 μg m-3, an interquartile range (4.7 μg m-3) increase in NO2 exposure was associated with elevated incident risks of Alzheimer's disease (hazard ratio 1.18; 95% confidence interval 1.05, 1.32) and vascular dementia (1.25; 95% confidence interval 1.07, 1.46), respectively. The associations were also observed with specific grey matter and white matter phenotypes. The findings suggest that updating a lower limit for ambient NO2 may yield significant benefits.</p>
12 Keywords
- Aged
- Air Pollutants
- Air Pollution
- Brain
- Environmental Exposure
- Female
- Humans
- Male
- Middle Aged
- Neurodegenerative Diseases
- Nitrogen Dioxide
- United Kingdom
10 Authors
- Yujia Bao
- Yongxuan Li
- Ne Qiang
- Yanqiu Zhou
- Mike Z He
- Chen Shen
- Xiaobei Deng
- Jie Yin
- Lefei Han
- Jinjun Ran
1 Application
| Application ID | Title |
|---|---|
| 99001 | Gene-environment interaction analysis on age-related diseases |
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