| Title: | Serum lipid levels and risk of lymphoid malignancies in the UK Biobank study |
| Journal: | British Journal of Cancer |
| Published: | 17 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40962848/ |
| DOI: | https://doi.org/10.1038/s41416-025-03196-x |
Publication 19481
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Abstract
BackgroundAbnormal circulating lipid levels have been suggested in relation to lymphoid malignancy (LM) risk.MethodsWe studied UK Biobank participants (n = 403,625) with serum data for cholesterol (total [TC], high-density lipoprotein [HDL], direct low-density lipoprotein [LDL]), triglycerides (TG), and apolipoproteins A1 and B (ApoA1, ApoB). We conducted principal component (PC) analysis and multivariate Cox regression models to estimate hazard ratio (HR) overall, by lipid-lowering drug use and follow-up interval.ResultsDuring an average of 10.5 years of follow-up, 3006 incident LMs occurred (including 667 multiple myelomas [MM], 2193 non-Hodgkin lymphomas [NHL]). Among medication non-users, most lipid levels were inversely associated with risk of most endpoints (HRQ4vsQ1range: 0.37 to 0.79), especially closer to diagnosis. In contrast LDL/HDL ratio and PC1 (highly loaded in LDL and ApoB) were consistently positively associated with chronic/small lymphocytic leukaemia risk in each follow-up period and with NHL and B-cell NHL risk within 5 years. Further, LD, ApoB and TG levels were positively associated with MM risk after 10+ years (HR1-SDrange = 1.26 to 1.60).ConclusionLipid depletion closer to LM diagnosis might reflect cancer cell metabolism and warrants further work examining individuals with precursor conditions. The MM-specific long-term risk might reflect the known MM-obesity association.</p>
8 Authors
- Sara Hermosa
- Yolanda Benavente
- Elena Cabezudo
- Juan Sainz
- Marta Farràs
- Laia Alemany
- Brenda M. Birmann
- Delphine Casabonne
1 Application
| Application ID | Title |
|---|---|
| 52433 | Prospective study of risk factors for multiple myeloma and its precursors in the context of the UK Biobank Cohort study |
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