| Title: | Relationship of high-density lipoprotein cholesterol, average size, and subclasses by size with the risk of fractures |
| Journal: | Precision Nutrition |
| Published: | 26 Sep 2025 |
| DOI: | https://doi.org/10.1097/pn9.0000000000000117 |
| URL: | http://dx.doi.org/10.1097/pn9.0000000000000117 |
Publication 19400
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Abstract
To evaluate the association of high-density lipoprotein cholesterol (HDL-C) concentrations, HDL particle (HDL-P) average size, and concentrations of HDL-P subclasses by size with new-onset fractures. A total of 380,733 participants free of fractures and who had HDL-C measurements available in the UK Biobank were included. The study outcome was new-onset fractures, ascertained by hospital inpatient data and the death registry. During a median follow-up of 12.4 years, 18,710 (4.9%) participants were documented as having new-onset fractures. HDL-C concentrations (per standard deviation [SD] increment, adjusted hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 1.09-1.13), HDL-P average size (per SD increment, adjusted HR: 1.12, 95% CI: 1.06-1.19), and very large-sized HDL-P concentrations (per SD increment, adjusted HR: 1.06, 95% CI: 1.01-1.12) were positively associated with the risk of new-onset fractures. Small-sized HDL-P concentrations were inversely associated with the risk of new-onset fractures (per SD increment, adjusted HR: 0.94, 95% CI: 0.91-0.98). Large-sized HDL-P concentrations (per SD increment, adjusted HR: 1.07, 95% CI: 0.99-1.14) and medium-sized HDL-P concentrations (per SD increment, adjusted HR: 0.98, 95% CI: 0.92-1.03) were not significantly associated with the risk of new-onset fractures. The increased risk of fractures at high concentrations of HDL-C was attributed to large- and very large-sized HDL-P concentrations. Higher HDL-C concentrations were associated with a significantly higher risk of new-onset fractures. Very large-sized HDL-P concentrations showed a positive association, while small-sized HDL-P concentrations showed an inverse association with new-onset fractures. The increased risk of fractures at high concentrations of HDL-C was attributed to the large- and very large-sized HDL-P concentrations.</p>
8 Authors
- Ziliang Ye
- Sisi Yang
- Yanjun Zhang
- Yuanyuan Zhang
- Xiaoqin Gan
- Hao Xiang
- Yu Huang
- Xianhui Qin
1 Application
| Application ID | Title |
|---|---|
| 73201 | Identification of residual risks of non-infectious chronic diseases |
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