| Title: | Study on the correlation between the number of cardiometabolic diseases and the risk of cataracts in the elderly population |
| Journal: | Chinese Journal of Geriatrics |
| Published: | 14 Oct 2025 |
| DOI: | https://doi.org/10.3760/cma.j.issn.0254-9026.2025.10.014 |
Publication 19188
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Abstract
Objective To evaluate the cumulative relationship between individual cardiometabolic diseases(CMDs)and the incidence of cataract in the elderly. Methods This study was a prospective cohort study based on the UK Biobank, including 165 222 participants without cataract at baseline, aged 60.0 to 74.0 years, with an average age of(64.9±2.9)years, including 76 712 males(46.4%)and 88 510 females(53.6%). The exposure in this study was CMDs(including coronary heart disease, stroke, diabetes, and hypertension), and the outcome was the incidence of cataract.The Cox proportional hazards model was used to evaluate the cumulative hazard ratio( HR )and 95% confidence interval( CI )of the number of CMDs and cataract occurrence in the elderly. Results After a median follow-up of 13.65 years, 35, 933 cataract events were observed.After adjusting for various factors, the HRs of cataract incidence in elderly patients with 1, 2, and 3 or more CMDs compared with those without CMDs were 1.11( HR =1.11, 95% CI : 1.08~1.14, P <0.001), 1.38( HR =1.38, 95% CI : 1.33~1.43, P <0.001), and 1.80( HR =1.80, 95% CI : 1.68-1.93, P <0.001), respectively.There was a significant dose-cumulative effect between the number of CMDs and the risk of cataract( HR =1.17, 95% CI : 1.15~1.19, P <0.001). Conclusions The coexistence of CMDs in the elderly is an important risk factor for cataract development, and the risk of cataract increases in a dose-cumulative manner with the increase in the number of CMDs, suggesting that emphasizing health management of CMDs in the elderly population may help reduce the incidence of cataract.</p>
5 Authors
- 曹容
- 于静芳
- 何玲芳
- 赵臣轩
- 潘玮
Enabling scientific discoveries that improve human health