| Title: | Long-term risk of irritable bowel syndrome associated with triglyceride-glucose related indices: a large-scale prospective cohort study |
| Journal: | Therapeutic Advances in Gastroenterology |
| Published: | 14 Oct 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42065095/ |
| DOI: | https://doi.org/10.1177/17562848251383796 |
Publication 19184
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Abstract
Background: Insulin resistance (IR) may play a crucial role in irritable bowel syndrome (IBS) pathogenesis. However, it remains unclear whether triglyceride-glucose (TyG)-related indices, useful biomarkers for assessing IR, are associated with IBS development.</p>
Objectives: To investigated the link between baseline TyG-related indices and incident IBS.</p>
Design: A prospective, population-based cohort study.</p>
Methods: Participants free of IBS with available TyG-related indices (TyG-waist circumference (TyG-WC), TyG-waist-to-height ratio (TyG-WHtR), and TyG-body mass index (TyG-BMI)) at enrollment were included (N = 356,904). Primary endpoint was incident IBS. Cox regression was used to evaluate the association between TyG-related indices and IBS.</p>
Results: During a median 14.6 years of follow-up (5,023,899 person-years), 7381 (2.1%) participants developed IBS. The mean (standard deviation) level of baseline TyG index was 8.7(0.6), with 8.0 (0.2), 8.5 (0.1), 8.9 (0.1), and 9.5 (0.3) in quartile 1-4. Compared with the lowest quartile, the highest quartile of all TyG-related indices was significantly associated with greater risk of incident IBS (TyG hazard ratio (HR) = 1.24, 95% confidence interval (CI): 1.16-1.33, <0.001; TyG-WC HR = 1.25, 95% CI: 1.16-1.34, <0.001; TyG-WHtR HR = 1.24, 95% CI: 1.16-1.33, <0.001; TyG-BMI HR = 1.15, 95% CI: 1.07-1.23, <0.001). Meanwhile, per standardized deviation increment of TyG-related indices were also associated with 6%-9% greater risk of IBS (TyG HR = 1.09, 95% CI: 1.07-1.12; TyG-WC HR = 1.09, 95% CI: 1.07-1.12; TyG-WHtR HR = 1.09, 95% CI: 1.06-1.11; TyG-BMI HR = 1.06, 95% CI: 1.03-1.08). Similar results were observed in various sensitivity analyses and subgroup analysis.</p>
Conclusion: Higher TyG-related indices are linked to higher risk of incident IBS, highlighting the importance of IR in IBS pathogenesis.</p>
6 Authors
- Haorui Liu
- Si Liu
- Qian Zhang
- Shutian Zhang
- Shengtao Zhu
- Shanshan Wu
1 Application
| Application ID | Title |
|---|---|
| 74444 | Common risk factors and prognosis of inflammatory bowel disease and irritable bowel syndrome |
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