| Title: | Delirium, genetic susceptibility and Parkinson's disease progression: a community- and UK biobank-based matched cohort study |
| Journal: | Aging & Mental Health |
| Published: | 4 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41186289/ |
| DOI: | https://doi.org/10.1080/13607863.2025.2581102 |
Publication 19033
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Abstract
OBJECTIVES: While various psychological factors increase Parkinson's disease (PD) risk, delirium's role remains unexplored. This study examined whether delirium is associated with PD incidence and identified potential modifying factors.</p>
METHOD: We conducted a matched cohort study using UK Biobank data, including 6,254 patients with first-time delirium and 31,270 matched unexposed individuals. Cox proportional hazards models assessed PD risk following delirium, evaluating effect modification by age, sex, education, BMI, depression, frailty, and polygenic risk scores.</p>
RESULTS: During follow-up (median: 1,011 days for exposed vs 1,678 days for unexposed), 2% of delirium patients developed PD vs 1% of controls. Delirium was associated with significantly increased PD risk (HR: 3.97; 95% CI: 2.97-5.33). Education level significantly modified this association, with higher education linked to greater risk (College: HR 6.57; Non-college: HR 3.70). Age, sex, BMI, frailty, and polygenic risk scores did not significantly alter the association.</p>
CONCLUSION: Delirium is a significant and potentially modifiable risk factor for PD, highlighting the clinical importance of its prevention and management, particularly in highly educated individuals.</p>
8 Authors
- Mengjie Li
- Wen Duan
- Yanmei Feng
- Zhiyun Wang
- Xiaoyan Hao
- Shuangjie Li
- Shilei Sun
- Changhe Shi
1 Application
| Application ID | Title |
|---|---|
| 221671 | Identification of potential Genetic and Environmental Risk Factors and risk factor Interactions in Brain Ageing related Diseases and Phenotypes |
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