About
Non-communicable diseases, also known as chronic diseases, are the leading cause of death and disability worldwide. With rapid population ageing and increased life expectancy, the coexistence of two or more chronic diseases, termed as multimorbidity, has become a growing public health concern. However, in contrast to a large number of researches focusing on a single chronic disease, studies investigating the mutual relation among non-communicable diseases and the phenomenon of multimorbidity are far from adequate. Therefore, this study aims to make an in-depth investigation into the patterns, outcomes and predictors of non-communicable diseases and multimorbidity.
Based on the unique UK Biobank resource, we will establish the causal network of non-communicable diseases and identify specific patterns of multimorbidity. In addition, the impact of major non-communicable diseases and multimorbidity on health impairment and healthcare system will be evaluated. At last, we will identify shared risk factors and pathological mechanisms for common non-communicable diseases, and provide effective prediction models for disease clusters and multimorbidity.
We intend to carry out our research with a three-year duration. The findings in this study are expected to provide scientific evidence for the prevention, intervention and care of non-communicable diseases and multimorbidity.
15 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|
| 13648 | A large study of metabolomics reveals common and distinct metabolic biomarkers for type 2 diabetes, coronary heart disease, and stroke | Yanqiang Lu (+9) | 2024 | American Journal of Epidemiology |
| 11725 | Adherence to the EAT-Lancet diet and incident depression and anxiety | Xujia Lu (+7) | 2024 | Nature Communications |
| 19675 | Adherence to the EAT-Lancet diet, plasma proteomics and the risk of chronic obstructive pulmonary disease | Xujia Lu (+7) | 2025 | Thorax |
| 19625 | Association of Plasma Omega-3 Fatty Acids With POAG | Jia-Yan Kai (+7) | 2025 | Investigative Ophthalmology & Visual Science |
| 10319 | Associations of handgrip strength with morbidity and all-cause mortality of cardiometabolic multimorbidity | Yanqiang Lu (+7) | 2022 | BMC Medicine |
| 13475 | Habitual Coffee, Tea, and Caffeine Consumption, Circulating Metabolites, and the Risk of Cardiometabolic Multimorbidity | Xujia Lu (+9) | 2024 | The Journal of Clinical Endocrinology & Metabolism |
| 19516 | Identifying genetic variants associated with sugar intake and appraising the genetic correlations with cardiovascular outcomes | Suzanne Janzi (+8) | 2025 | Clinical Nutrition |
| 14485 | Life's Essential 8 and risks of mortality and cardiovascular morbidity in individuals with PRISm and its associations with transition trajectories of PRISm | Yang Geng (+5) | 2025 | Thorax |
| 10497 | Preserved Ratio Impaired Spirometry and Risks of Macrovascular, Microvascular Complications and Mortality Among Individuals With Type 2 Diabetes | Guochen Li (+9) | 2023 | CHEST Journal |
| 11189 | Preserved Ratio Impaired Spirometry, Metabolomics, and the Risk of Type 2 Diabetes | Guochen Li (+5) | 2023 | The Journal of Clinical Endocrinology & Metabolism |
| 19206 | Preserved ratio impaired spirometry, plasma proteomics, and incident heart failure | Yang Geng (+7) | 2025 | Journal of Advanced Research |
| 13844 | Role of Pulmonary Function in Predicting New-Onset Cardiometabolic Diseases and Cardiometabolic Multimorbidity | Guochen Li (+4) | 2022 | CHEST Journal |
| 7050 | Role of depression in the development of cardiometabolic multimorbidity: Findings from the UK Biobank study | Yanan Qiao (+5) | 2022 | Journal of Affective Disorders |
| 19291 | Visual Impairment and Risk of All-Cause and Cause-Specific Mortality: Results From Two Prospective Cohort Studies | Xing-Xuan Dong (+6) | 2025 | American Journal of Ophthalmology |
| 19503 | Weight-adjusted-waist index, estimated glucose disposal rate, C-reactive protein, and mortality risks among individuals with type 2 diabetes: 2 prospective cohort studies in China and the United Kingdom | Yang Geng (+9) | 2025 | American Journal of Clinical Nutrition |
