| Title: | Acquired Risk Factors and Incidence of Metabolic Cardiovascular Disease According to age and Genetic Susceptibility |
| Lead Institution: | Qilu Hospital of Shandong University |
| Principal investigator: |
Application 151350
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About
The social environment, dietary habits, lifestyle, clinical comorbidities, and body metabolism play a key role in the global burden of metabolic cardiovascular disease. Therefore, identification and effective management of modifiable factors are essential for the prevention and control of CVD. Given the differences between populations, the importance of various risk factors varies across populations. Therefore, by utilising data from the UK Biobank, we plan to calculate group attributable risks for metabolic CVD risk factors in different age and genetic susceptibility groups. Subsequently, we will rank these risk factors according to group attributable risk to identify high-risk, modifiable factors. In addition, we will investigate how metabolic cardiovascular risk factors vary with individual age and genetic susceptibility. This study will build on existing evidence and support national and international guidelines for early intervention in the management of metabolic cardiovascular disease. Understanding the interactions between genetics and metabolic cardiovascular risk factors will contribute to more precise management of metabolic cardiovascular disease in the future.5 Publications
Enabling scientific discoveries that improve human health