| Title: | Lifestyle Factors, Cardiometabolic Diseases, and Subsequent Cancer Risk: Evidence from Two Large Prospective Cohort Studies |
| Journal: | Engineering |
| Published: | 1 Jul 2026 |
| DOI: | https://doi.org/10.1016/j.eng.2026.07.009 |
Publication 21453
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Abstract
Cardiometabolic diseases (CMDs) are associated with increased cancer risk; however, the role of healthy lifestyle factors (LFs) in mitigating this risk remains unclear. Using data from 856 568 adults in the China Kadoorie Biobank (n = 461 047) and the UK Biobank (n = 395 521), we prospectively examined the associations of CMDs and cardiometabolic multimorbidity (CMM) with subsequent cancer risk and evaluated the potential protective effects of five low-risk LFs: no tobacco smoking, no excessive alcohol drinking, high physical activity, healthy dietary habits, and healthy body shape. We demonstrated that individuals with CMDs, especially those with multimorbidity, faced a significantly higher risk of cancer in both cohorts. Healthy LFs, particularly no tobacco smoking and high physical activity, were associated with a lower cancer risk following CMD onset. Moreover, adopting at least four healthy lifestyles could prevent an estimated 11.50%-15.30% of cancer cases among those with CMD. These findings highlight the importance of lifestyle interventions in cancer prevention, particularly for those with preexisting cardiometabolic conditions.</p>
22 Authors
- Xia Zhu
- Yuting Han
- Qiufen Sun
- Meng Zhu
- Caiwang Yan
- Canqing Yu
- Dianjianyi Sun
- Pei Pei
- Yue Jiang
- Jiaping Chen
- Chunxiao Liao
- Ling Yang
- Yiping Chen
- Huaidong Du
- Juncheng Dai
- Hongxia Ma
- Zhengming Chen
- Zhibin Hu
- Jun Lv
- Hongbing Shen
- Liming Li
- Guangfu Jin
1 Application
| Application ID | Title |
|---|---|
| 82535 | Attributable risk of genetic, lifestyle and environmental factors on the incidence and mortality of pan-cancer |
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