| Title: | Association of triglyceride-glucose index (TyG) and a body shape index (ABSI) with cognitive decline and dementia risk |
| Journal: | PLOS ONE |
| Published: | 22 Jul 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42485421/ |
| DOI: | https://doi.org/10.1371/journal.pone.0354418 |
| URL: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0354418&type=printable |
Publication 21408
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Abstract
BACKGROUND: Longitudinal evidence linking the body shape index (ABSI) to dementia and its subtypes remains scarce. Furthermore, the use of ABSI and TyG-ABSI as predictors of cognitive decline and dementia is infrequent. Therefore, this study aimed to examine the relationships between the triglyceride-glucose (TyG) index, ABSI, and TyG-ABSI indices and their predictive value for cognitive decline and dementia risk.</p>
METHODS: This study included 370,744 participants from the UK Biobank. The TyG and ABSI indices were calculated using their respective formulas, while the TyG-ABSI index was derived by multiplying TyG and ABSI. Cognitive decline was defined as scoring in the bottom 25% on cognitive tests, while dementia was diagnosed from first-recorded incidents and algorithmically-defined outcomes. Logistic regressions were employed to assess the associations of TyG, ABSI and TyG-ABSI indices with cognitive decline; Cox regressions were used to analyze the associations of these indices with the risk of all-cause dementia (ACD) and its subtypes.</p>
RESULT: The TyG, ABSI, and TyG-ABSI indices were all significantly associated with cognitive decline. Additionally, compared with the lowest quartiles, the highest quartiles of TyG, ABSI and TyG-ABSI indices were associated with a significantly increased risk of ACD by 33% (HR = 1.33, 95% CI: 1.13-1.57), 79% (HR = 1.79, 95% CI: 1.65-1.94) and 67% (HR = 1.67, 95% CI: 1.54-1.82), respectively. These indices were also significantly associated with the risk of Alzheimer's disease (AD) and vascular dementia (VD) (all P < 0.05).</p>
CONCLUSION: The TyG, ABSI, and TyG-ABSI indices are significantly and positively linked to the risk of cognitive decline and dementia.</p>
9 Keywords
- Aged
- Blood Glucose
- Cognitive Dysfunction
- Dementia
- Female
- Humans
- Male
- Risk Factors
- Triglycerides
9 Authors
- Shuangshuang Yang
- Lili Cui
- Jinxin Zhang
- Ying Yang
- Junhao Huo
- Yuyan Ding
- Jingni Zhang
- Shulan He
- Jiangping Li
1 Application
| Application ID | Title |
|---|---|
| 98124 | Understanding the patterns of multimorbidity, and the role of environmental, lifestyle-related, psychological and genetic factors |
Enabling scientific discoveries that improve human health