| Title: | Borderline Forced Expiratory Volume in 1 Second to Forced Vital Capacity and Low Forced Expiratory Volume in 1 Second Predict Disease Progression in High-Risk Populations With COPD. |
| Journal: | Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation |
| Published: | 22 Jul 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/42172581/ |
| DOI: | https://doi.org/10.15326/jcopdf.2025.0700 |
Publication 21401
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Abstract
Background and objectives: The ratio of forced expiratory volume in 1 second (FEV1) to forced vital capacity (FVC), and the proportion of FEV1 percentage predicted are used to diagnose and determine disease severity in chronic obstructive pulmonary disease (COPD). This study investigated the prognostic capabilities of borderline FEV1 to FVC and low FEV1 on disease progression among a population at high risk for COPD.</p>
Methods: This study utilized 2-year follow-up data from the National COPD Screening Program. Participants were divided into 4 groups according to FEV1 to FVC and FEV1: normal ratio with normal FEV1, borderline ratio with normal FEV1, normal ratio with low FEV1, and borderline ratio with low FEV1. The outcomes were FEV1 decline and progression to airway obstruction.</p>
Results: This study included a total of 2969 patients at high risk for COPD. Compared with the normal ratio with normal FEV1 group, the borderline ratio with normal FEV1 (adjusted odds ratio [OR]=1.81, 95% confidence interval [CI]: 1.34 to 2.44) and borderline ratio with low FEV1 (adjusted OR=2.32, 95%CI: 1.46 to 3.69) groups showed higher risks of developing airway obstruction, while the normal ratio with low FEV1 group showed no significant change in risk (adjusted OR=1.31, 95% CI: 0.83 to 2.07). Further, the findings also were proven true in the general population with longer follow years by using data from the U.K. Biobank (the borderline ratio with normal FEV1 group: adjusted hazard ratio [HR] = 2.92, 95% CI: 2.28 to 3.74; and borderline ratio with low FEV1 group: adjusted HR = 4.53, 95% CI: 3.21 to 6.38).</p>
Conclusion: Participants with borderline FEV1/FVC have a higher risk of developing airway obstruction, regardless of a decline in FEV1.</p>
16 Authors
- Xingyao Tang
- Wei Li
- Jieping Lei
- Hongtao Niu
- Mingshui Shi
- Jisong Yan
- Yaodie Peng
- Yanan Cui
- Tingting Huang
- Yong Li
- Jun Pan
- Chunyu Zhang
- Cunbo Jia
- Xu Chu
- Ting Yang
- Ke Huang
1 Application
| Application ID | Title |
|---|---|
| 277441 | Gene-environment interaction and its differential pathogenicity in chronic respiratory diseases across various behavioral lifestyles. |
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