| Title: | Glycemic status, early-onset and late-onset dementia, dementia-free lifespan, and brain structure: A population-based cohort study |
| Journal: | Diabetes Research and Clinical Practice |
| Published: | 18 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40975178/ |
| DOI: | https://doi.org/10.1016/j.diabres.2025.112909 |
| URL: | https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(25)00923-4/pdf |
Publication 19471
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Abstract
AIMS: To evaluate associations of glycemic status with incident early-onset dementia (EOD) and late-onset dementia (LOD), dementia-free life expectancy, brain MRI structure measures, as well as the mediation pathway of depressive episode.</p>
METHODS: A population-based cohort study based on UK Biobank, enrolling a total of 286 743 (mean [SD] age, 51.5 [5.9] years) and 330 103 participants (mean [SD] age, 60.7 [5.0] years) for analyzing EOD and LOD, respectively. Incident EOD was defined as dementia diagnosis before age 65, and LOD defined as dementia after age 65.</p>
RESULTS: Diabetes participants with optimal glycemic control respectively had a 47 % lower EOD incidence and a 17 % lower LOD incidence, up to 3.2 years longer dementia-free lifespan at age 50, and better dementia-related brain structure measures, compared to counterparts with worse glycemic status. Incident depressive episode mediated 18.8 % (P = 0.014) and 7.8 % (P < 0.001) of associations between glycemic status with EOD and LOD, respectively.</p>
CONCLUSIONS: Better glycemic status was associated with reduced EOD and LOD risks, prolonged dementia-free lifespan, and brain MRI measures, partiality mediated by depressive episode. These findings support the potential significance of reaching ideal glycemic status to prevent dementia onset and prolong dementia-free longevity at the early pre-symptomatic stage in young diabetes.</p>
5 Authors
- Chenglong Li
- Daijun He
- Chao Yang
- Luxia Zhang
- Rodica Pop-Busui
1 Application
| Application ID | Title |
|---|---|
| 90018 | Environment, genotype, AI-derived phenotype, and the risk of cardiovascular diseases, metabolic diseases, and chronic kidney disease |
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