| Title: | Brain-heart-eye axis revealed by multi-organ imaging genetics and proteomics |
| Journal: | Nature Biomedical Engineering |
| Published: | 30 Sep 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41028329/ |
| DOI: | https://doi.org/10.1038/s41551-025-01506-5 |
| URL: | https://www.nature.com/articles/s41551-025-01506-5.pdf |
Publication 19372
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Abstract
Multi-organ research investigates interconnections among multiple human organ systems, enhancing our understanding of human aging and disease mechanisms. Here we use multi-organ imaging, individual- and summary-level genetics, and proteomics data consolidated via the MULTI Consortium to delineate a brain-heart-eye axis using brain patterns of structural covariance (PSCs), heart imaging-derived phenotypes (IDPs) and eye IDPs. We find that proteome-wide associations of the PSCs and IDPs show within-organ specificity and cross-organ interconnections. Pleiotropic effects of common single-nucleotide polymorphisms are observed across multiple organs, and key genetic parameters are estimated for single-nucleotide polymorphism-based heritability, polygenicity and selection signatures across the three organs. A gene-drug-disease network shows the potential of drug repurposing for cross-organ diseases. Co-localization and causal analyses reveal cross-organ causal relationships between PSC/IDP and chronic diseases, such as Alzheimer's disease, heart failure and glaucoma. Finally, integrating multi-organ/omics features improves prediction for systemic disease categories and cognition compared with single-organ/omics features, providing future avenues for modelling human aging and disease.</p>
9 Authors
- Aleix Boquet-Pujadas
- Filippos Anagnostakis
- Michael R. Duggan
- Cassandra M. Joynes
- Arthur W. Toga
- Zhijian Yang
- Keenan A. Walker
- Christos Davatzikos
- Junhao Wen
1 Application
| Application ID | Title |
|---|---|
| 647044 | MULTI: modeling human aging and disease via multi-organ and multi-omics biomedical data |
Enabling scientific discoveries that improve human health