| Title: | Association of sleep and dyslipidemia with migraine incidence in a cohort of 309,475 participants |
| Journal: | Scientific Reports |
| Published: | 11 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41219287/ |
| DOI: | https://doi.org/10.1038/s41598-025-22994-0 |
Publication 18970
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Poor sleep quality is an essential factor in various neurological disorders. However, prospective evidence and the underlying biological mechanisms of sleep quality in patients with new-onset migraines are lacking. This study examined the prospective association between sleep quality, migraine incidence, and the underlying biological mechanisms. This prospective cohort study included 309,475 individuals without headaches at baseline and with complete sleep behaviour measurements from the UK Biobank. Sleep quality was assessed based on chronotype, sleep duration, insomnia, snoring, and excessive daytime sleepiness. Cox proportional hazards models were used to estimate the association between sleep quality scores and migraine incidence. Mediation analyses were performed to investigate the potential mediating effects of metabolic syndrome and its components, biomarkers, and metabolites on this association. Over a median follow-up of 13.6 years, 3,891 participants (1.3%) developed migraines. The Cox model results revealed a significant negative relationship between baseline sleep scores and migraine incidence. Sleep scores were defined such that higher scores indicated better sleep quality. Higher sleep scores were associated with a decreased risk of new-onset migraines (fully adjusted hazard ratio: 0.88, 95% confidence interval [CI]: 0.85 −0.90 per unit increase). Additionally, adequate sleep duration, an absence of insomnia, and excessive daytime sleepiness were independently associated with a significantly reduced migraine risk. Dyslipidemia mediated the association between sleep score and migraine incidence, with a mediation proportion of 3.28% (95% CI 1.37−5%). Our study revealed an association between sleep quality and migraine risk and the potential role of dyslipidemia in mediating this association.</p>
16 Keywords
- Adult
- Aged
- Dyslipidemias
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Migraine Disorders
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sleep
- Sleep Initiation and Maintenance Disorders
- Sleep Quality
- United Kingdom
8 Authors
- Jing-Hao Wu
- Zi-Han Zhou
- Xin-Yu Li
- Wen-Jun He
- Wen-Kai Yu
- Kai Gao
- Yue Xie
- Yu-Sheng Li
1 Application
| Application ID | Title |
|---|---|
| 186039 | Investigating the genetics, behavior, environmental and clinical determinants and their interaction of nervous system diseases and other non-communicated diseases |
Enabling scientific discoveries that improve human health