| Title: | Polygenic Risk for Pre-Eclampsia and the Long-Term Risk of Incident Hypertension and Cardiovascular Disease: A Population-Based Cohort Study |
| Journal: | BJOG An International Journal of Obstetrics & Gynaecology |
| Published: | 14 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41236086/ |
| DOI: | https://doi.org/10.1111/1471-0528.70072 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1471-0528.70072 |
Publication 18934
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Abstract
OBJECTIVE: To investigate whether genetic predisposition to pre-eclampsia (PE), measured by a polygenic risk score (PRS), is associated with incident hypertension and cardiovascular disease (CVD) after delivery in Asian women.</p>
DESIGN: Prospective population-based cohort study.</p>
SETTING: Data were utilised from the Korean Genome and Epidemiology Study and additional multicentre cohorts.</p>
POPULATION: 35 872 parous Korean women aged 40-80 years at last surveillance, with genotype data, no history of hypertension or CVD before delivery, and complete clinical information. For external validation, 559 parous Korean women were included.</p>
METHODS: The PE-PRS was calculated for Asian women, and the study population was divided into the high PE-PRS and low PE-PRS groups. The long-term risks of incident hypertension and CVD (ischaemic heart disease or stroke) after delivery were compared between the groups.</p>
MAIN OUTCOME MEASURES: Incident hypertension and CVD after delivery.</p>
RESULTS: Women in the high PE-PRS group had an increased risk of developing hypertension (adjusted hazard ratio [aHR] 1.25, 95% CI 1.17-1.34) and ischaemic heart disease (aHR 1.28, 95% CI 1.07-1.54) compared to the low PE-PRS group. The risk of hypertension was highest among women with both a history of PE and a high PE-PRS.</p>
CONCLUSIONS: Genetic predisposition to PE, as measured by the PE-PRS, is associated with an elevated risk of incident hypertension and ischaemic heart disease in Asian women. These findings suggest the potential utility of the PE-PRS as a complementary tool in assessing individualised hypertension risk in parous women.</p>
13 Authors
- Eun-Saem Choi
- Sang-Hyuk Jung
- Young Mi Jung
- Chan-Wook Park
- Joong Shin Park
- Jong Kwan Jun
- Jaeyoung Kim
- Beomsu Kim
- Chamlee Cho
- Injeong Shim
- Dokyoon Kim
- Hong-Hee Won
- Seung Mi Lee
1 Application
| Application ID | Title |
|---|---|
| 68416 | The effect of genetic variants on pregnancy complications and its long term health outcomes |
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