| Title: | Association between sepsis and all-cause and cause-specific premature mortality: a prospective cohort study |
| Journal: | Frontiers in Public Health |
| Published: | 14 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41323595/ |
| DOI: | https://doi.org/10.3389/fpubh.2025.1666675 |
| URL: | https://public-pages-files-2025.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2025.1666675/pdf |
Publication 18933
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Abstract
Objective: This study aimed to examine the association between sepsis, including its subtypes, and all-cause and cause-specific premature mortality.</p>
Methods: This population-based prospective cohort study included 371,558 participants from the UK Biobank recruited between 2006 and 2010. Sepsis was identified from hospital records using ICD-10 codes. Cox proportional-hazards models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for premature mortality.</p>
Results: Among 371,558 participants, 47,149 (12.7%) were diagnosed with sepsis, including 21,148 with implicit sepsis, 620 with explicit sepsis, and 25,381 with both. Sepsis was associated with a higher risk of all-cause premature mortality (aHR 2.36, 95% CI 2.26-2.46). Cause-specific analyses showed elevated risks for cardiovascular (aHR 2.35, 95% CI 2.18-2.54), respiratory (aHR 7.30, 95% CI 6.23-8.55), cancer-related (aHR 1.76, 95% CI 1.66-1.87), and infection-related premature mortality (aHR 9.75, 95% CI 6.97-13.62). Participants with explicit sepsis alone had elevated risk of all-cause mortality (aHR 1.72, 95% CI 1.21-2.45), which was lower than implicit sepsis alone (aHR 2.05, 95% CI 1.94-2.17) and highest for those with both implicit and explicit sepsis (aHR 2.60, 95% CI 2.48-2.73). Risks were more pronounced in participants with older age, multiple comorbidities, and unhealthy lifestyle (P interaction < 0.001).</p>
Conclusion: Sepsis, especially implicit and combined implicit-explicit sepsis, was associated with increased risks of all-cause and cause-specific premature mortality. These associations were stronger in older participants, those with comorbidities, and unhealthy lifestyles.</p>
13 Keywords
- Adult
- Aged
- Cause of Death
- Female
- Humans
- Male
- Middle Aged
- Mortality, Premature
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Sepsis
- United Kingdom
9 Authors
- Wenhui Kang
- Jiyong Zhong
- Fei Wang
- Wulin Li
- Zhenfeng Dou
- Shaoguan Huang
- Shaohua Yin
- Lei Yuan
- Dali You
1 Application
| Application ID | Title |
|---|---|
| 99709 | Risk factor and causal association detection in common diseases |
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