| Title: | Sleep patterns and the risk of psoriatic disease: genetic predisposition and metabonomics |
| Journal: | British Journal of Dermatology |
| Published: | 15 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41240371/ |
| DOI: | https://doi.org/10.1093/bjd/ljaf463 |
Publication 18919
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Abstract
BACKGROUND: The longitudinal impact of comprehensive sleep patterns on incident psoriatic disease (PsD) and the potential mediating effects are unclear.</p>
OBJECTIVES: To investigate the associations of sleep patterns with PsD risk, alongside the role of genetic predisposition and the potential mediating effects of serum metabolites.</p>
METHODS: This prospective cohort study included 399 912 participants without PsD registered in UK Biobank. Cox proportional hazard models were used to examine the association between sleep patterns, genetic risk of PsD and the overall risk of PsD. Cross-product interaction terms between polygenic risk score (PRS) categories and sleep patterns were incorporated into the fully adjusted models, and the relative excess risk due to interaction (RERI) was calculated to examine additive interaction. Mediation analyses were used to identify specific metabolites as potential mediators of PsD.</p>
RESULTS: During a mean follow-up of 14.7 years, 4001 new cases of PsD were identified. Compared with those with high PRS and low sleep scores, participants with low PRS and high sleep scores had the lowest risk of PsD [hazard ratio 0.35, 95% confidence interval (CI) 0.28-0.43]. Although no significant interaction between PRS and sleep score was initially detected (P = 0.08), subsequent analyses using a median-dichotomized PRS revealed multiplicative (P = 0.003) and additive interactions (RERI 0.36, 95% CI 0.17-0.55; P < 0.001). Mediation analyses identified glycoprotein acetylation, the ratio of polyunsaturated fatty acids to monounsaturated fatty acids and alkaline phosphatase as partial mediators of the sleep-PsD association.</p>
CONCLUSIONS: Unfavourable sleep patterns significantly increase the risk of PsD, especially in people with a high genetic predisposition to PsD. This association is partially mediated by inflammatory and metabolic biomarkers, highlighting sleep optimization as a modifiable lifestyle factor for mitigating PsD risk.</p>
19 Keywords
- Adult
- Aged
- Biomarkers
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Humans
- Incidence
- Longitudinal Studies
- Male
- Metabolomics
- Middle Aged
- Multifactorial Inheritance
- Proportional Hazards Models
- Prospective Studies
- Psoriasis
- Risk Factors
- Sleep
- United Kingdom
12 Authors
- Ziyu Guo
- Zehao Luo
- Shiyu Zhang
- Yao Yu
- Zihua Wu
- Yangqian Chen
- Yuming Sun
- Furong Zeng
- Lin Shi
- Guowei Zhou
- Lixia Lu
- Guangtong Deng
1 Application
| Application ID | Title |
|---|---|
| 548711 | Unveiling distinct and shared germline genetic landscapes of multiple cancers and skin diseases through comparative whole-genome analysis |
Enabling scientific discoveries that improve human health