| Title: | Healthy plant-based dietary pattern is associated with a lower risk of rosacea |
| Journal: | Journal of the European Academy of Dermatology and Venereology |
| Published: | 18 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41255052/ |
| DOI: | https://doi.org/10.1111/jdv.70163 |
Publication 18889
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Abstract
BACKGROUND: Several plant-based dietary foods are associated with the rosacea risk, but the associations between plant-based dietary patterns and the risk of rosacea remain unclear.</p>
OBJECTIVES: We aimed to examine the associations of plant-based dietary patterns, represented by three plant-based diet indices (PDIs), with the risk of rosacea.</p>
METHODS: This prospective cohort study included 198,557 participants free of rosacea at baseline from the UK Biobank. Three PDIs (the overall plant-based diet index, PDI; the healthful plant-based diet index, hPDI; and the unhealthful plant-based diet index, uPDI) were calculated from 24-h dietary recalls based on 17 food groups. The primary outcome was the risk of rosacea. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).</p>
RESULTS: During a median follow-up of 13.46 years, 1075 new-onset rosacea cases were recorded. Each 10-point increase in the PDI and hPDI was associated with a 16% (95% CI: 0.76, 0.94) and 9% (95% CI: 0.82, 1.00) decrease in the risk of rosacea, respectively, whereas each 10-point increase in the uPDI was associated with a 12% (95% CI: 1.02, 1.24) increase in the risk. Compared with participants in the lowest PDI quintile, those in the highest PDI quintile had a lower risk of rosacea, with a HR of 0.78 (95% CI: 0.63, 0.95; p for trend = 0.004). In contrast, compared with participants in the lowest uPDI quintile, participants in the highest uPDI quintile had a higher risk of rosacea, with a HR of 1.23 (95% CI: 1.02, 1.48; p for trend = 0.046).</p>
CONCLUSIONS: A higher PDI or hPDI decreased the risk of rosacea, whereas a higher uPDI increased the rosacea risk. These findings suggest that adhering to an overall or a healthful plant-based pattern while avoiding an unhealthful plant-based pattern should be recommended as preventive strategies for rosacea.</p>
10 Authors
- Yue Zhang
- Fan Yang
- Wen-Rui Zheng
- Peng-yue Liu
- Xi-meng Zhang
- Jia-Cheng Liu
- Ting-Ting Gong
- Shan-Yan Gao
- Qi-Jun Wu
- Yan Wu
1 Application
| Application ID | Title |
|---|---|
| 211772 | Understanding the role of modifiable and genetic factors with sarcopenia in UK biobank: a longitudinal analysis |
Enabling scientific discoveries that improve human health