| Title: | Association Between Irritable Bowel Syndrome and Hypothyroidism: Insights from Large-Scale Population-Based Studies. |
| Journal: | Endocrine Metabolic & Immune Disorders - Drug Targets |
| Published: | 24 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41293922/ |
| DOI: | https://doi.org/10.2174/0118715303390590250928210823 |
Publication 18844
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Abstract
INTRODUCTION: Irritable Bowel Syndrome (IBS) and hypothyroidism are both common conditions that significantly affect patient health. This study examines the link between IBS and hypothyroidism, focusing on how IBS impacts hypothyroidism.</p>
METHODS: A retrospective cohort study using data from the UK Biobank (UKB) and a cross-sectional analysis from the National Inpatient Sample (NIS) were conducted. Propensity score matching was applied to control for confounding factors. Cox proportional hazards models (UKB) and logistic regression models (NIS) were used to evaluate the association between IBS and hypothyroidism. Subgroup analyses by age and sex were performed.</p>
RESULTS: The UKB cohort included 22,970 IBS patients (mean age 56.1 ± 7.94 years, 72.2% female) with a hypothyroidism prevalence of 4.1%, compared to 438,094 non-IBS participants (mean age 56.4 ± 8.12 years, 51.9% female) with a prevalence of 2.9%. In the NIS, 183,738 IBS patients had a hypothyroidism prevalence of 20.6%, compared to 10.3% in 20,298,589 non-IBS participants. After PSM, the hazard ratio (HR) for hypothyroidism in IBS patients was 1.21 (95% CI: 1.12-1.30, P < 0.001) in the UKB, and the odds ratio (OR) was 1.25 (95% CI: 1.23-1.27, P < 0.001) in the NIS. Subgroup analyses showed a higher risk for hypothyroidism in IBS patients, particularly those aged ≤65 years and females.</p>
CONCLUSIONS: IBS is associated with an increased risk of hypothyroidism. Clinicians should consider screening for thyroid dysfunction in IBS patients to improve patient outcomes.</p>
9 Authors
- Jing Wu
- Ziwei Liu
- Luna Liu
- Qian Liu
- Shiwei Sun
- Huijie Li
- Fei Li
- Meng Zhou
- Yongfeng Song
1 Application
| Application ID | Title |
|---|---|
| 89483 | Identifying risk factors and drug repurposing for chronic diseases: a longitudinal cohort study based on UK Biobank |
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