| Title: | Sweet Foods Intake and Risk of Pancreatic Diseases: A large cohort study from the UK Biobank |
| Journal: | Nutrition |
| Published: | 23 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41456479/ |
| DOI: | https://doi.org/10.1016/j.nut.2025.113032 |
Publication 18828
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Abstract
OBJECTIVES: Growing evidence has linked sweet food intake to obesity, diabetes, and mortality, but its association with pancreatic disease remains underexplored.</p>
METHODS: A total of 136 367 participants aged 40-69 y from the UK Biobank were included. Sweet food intake was assessed through dietary questionnaires, and pancreatic disease outcomes were identified using clinical and self-reported data. Multivariable Cox proportional hazards regression models were employed to estimate the hazard ratios (HRs) for pancreatic disease risk across quartiles of sweet food intake.</p>
RESULTS: During a median (interquartile range) follow-up of 11.6 (11.2-12.4) y, 348 pancreatic cancer events, 527 acute pancreatitis events, and 319 chronic pancreatitis events occurred. Higher sweet food intake was associated with an increased risk of chronic pancreatitis (HRQuartile 4 vs. Quartile 1: 1.87; 95% confidence interval [CI], 1.32-2.64; Ptrend < 0.001) but not with pancreatic cancer (HRQuartile 4 vs. Quartile 1: 1.11; 95% CI, 0.80-1.53; Ptrend = 0.60) or acute pancreatitis (HRQuartile 4 vs. Quartile 1: 0.95; 95% CI, 0.72-1.23; Ptrend = 0.65).</p>
CONCLUSIONS: Findings from this cohort study suggest that lower intake of sweet foods may reduce the risk of chronic pancreatitis.</p>
13 Authors
- Yuqi Liu
- Hanke Ma
- Yin Lu
- Donglin Jiang
- Ling Liu
- Yongjian Zhu
- Yacong Bo
- Peng Wang
- Jianxiang Shi
- Lin Shang
- Chensu Yang
- Hua Ye
- Qiaozhen Cai
1 Application
| Application ID | Title |
|---|---|
| 93398 | Investigating the risk factors of non-communicable chronic disease using biomarkers, lifestyle factors, and environmental factors |
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