| Title: | Lifespan Normative Models of White Matter Fractional Anisotropy: Applications to Early Psychosis |
| Journal: | Biological Psychiatry |
| Published: | 5 Aug 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40754177/ |
| DOI: | https://doi.org/10.1016/j.biopsych.2025.07.021 |
| URL: | https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)01379-4/pdf |
Publication 18706
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Abstract
BACKGROUND: This study presents large-scale normative models of white matter (WM) organization across the lifespan, using diffusion magnetic resonance imaging data from over 25,000 healthy individuals ages 0 to 100 years from multiple cohorts including the Human Connectome Project (HCP) Lifespan and UK Biobank. These models capture lifespan trajectories and interindividual variation in fractional anisotropy (FA), a marker of WM integrity.</p>
METHODS: By addressing non-Gaussian data distributions, self-reported race, and site effects, the models offer reference baselines across diverse ages and scanning conditions. We applied these FA models to the HCP Early Psychosis cohort and performed a multivariate analysis to map symptoms onto deviations from multimodal normative models using multiview sparse canonical correlation analysis.</p>
RESULTS: Our results reveal extensive WM heterogeneity in psychosis, which is not captured by group-level analyses, with key regions identified, including the right uncinate fasciculus and thalami.</p>
CONCLUSIONS: These normative models offer valuable tools for individualized WM deviation identification, improving precision in psychiatric assessments. All models are publicly available for community use.</p>
7 Authors
- Ramona Cirstian
- Natalie J Forde
- Hui Zhang
- Gerhard S Hellemann
- Christian F Beckmann
- Nina V Kraguljac
- Andre F Marquand
1 Application
| Application ID | Title |
|---|---|
| 23668 | Genetic and environmental factors including nutritional and lifestyle influences on neurodevelopmental disorders/traits (including impulsivity/compulsivity) and their brain correlates |
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