| Title: | Depression and risk of gastro-oesophageal reflux disease (GERD): results from the UK Biobank study |
| Journal: | BMC Gastroenterology |
| Published: | 8 Jan 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41507822/ |
| DOI: | https://doi.org/10.1186/s12876-025-04591-7 |
Publication 18676
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Abstract
BackgroundThis study investigated the association between depression and the incidence of gastro-oesophageal reflux disease (GERD) and examined whether the association interacts with age. The analysis was based on 457,958 participants aged 37-73 years from the UK-Biobank prospective cohort study.MethodsThe baseline examination started 2006 and the participants were followed up until 2019-2023 (median follow-up time 13.52 years [interquartile range12.62-14.27]). Depression at baseline and incident GERD at follow-up were defined through sources of the British health system (ICD-codes) and self-report. Multivariable adjusted Cox regression models were used for analysis. Formal tests for interaction with sex and age were conducted.ResultsParticipants who developed GERD during follow-up were characterized by an unhealthier lifestyle and more comorbidities than individuals without GERD. In multivariable analysis, depression was associated with incident GERD (Hazard ratio 1.51 [1.46,1.55]; P < 0.001). The association decreased with increasing age. There was no interaction with sex.ConclusionDepression and its psycho-physiological consequences may be associated with the development of GERD, in particular in middle-aged people. Consequently, increased attention of the treating physicians regarding an increased risk of GERD in depressed persons is important.</p>
5 Authors
- Julia Reizner
- Dennis Freuer
- Timo Schmitz
- Jakob Linseisen
- Christa Meisinger
1 Application
| Application ID | Title |
|---|---|
| 192645 | Development and evaluation of a risk score for screening of gastro-esophageal cancer and precursor lesions (RISC-GAP) |
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