| Title: | The Prime Diet Quality Score (PDQS), chronic disease and cause-specific mortality in UK Biobank: a prospective study |
| Journal: | European Journal of Nutrition |
| Published: | 17 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41843181/ |
| DOI: | https://doi.org/10.1007/s00394-025-03877-6 |
Publication 17357
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Abstract
PurposeThe Prime Diet Quality Score (PDQS) is a global food-based metric for assessing diet quality. We evaluated PDQS-measured diet quality in relation to mortality and major chronic disease outcomes in the UK Biobank.MethodsThis population-based cohort study included UK adults (40-69 years) recruited in 2006-2010 and followed until 2021. PDQS was derived from ≥ 2 dietary recalls. Multivariable Cox regression estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for total and cause-specific mortality, cardio-metabolic diseases (type 2 diabetes [T2D], cardiovascular disease [CVD], myocardial infarction [MI], stroke), respiratory diseases (chronic obstructive pulmonary disease [COPD], asthma), cancers (total, lung, colorectal, oesophageal, postmenopausal breast, prostate), neurodegenerative diseases (dementia, Parkinson's, anxiety, depression), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease (CKD), eczema, psoriasis, fracture, and osteoporosis.ResultsAmong 124,851 participants (mean age 59 ± 8 years), those in the highest PDQS quartile had lower mortality risks: total (HR 0.80, 95% CI 0.73-0.88), cancer (0.87, 0.77-0.98), respiratory (0.56, 0.37-0.87), and neurodegenerative (0.61, 0.39-0.96). Chronic morbidity risks were lower for T2D (0.73, 0.66-0.81), MI (0.80, 0.71-0.90), ischemic stroke (0.86, 0.74-1.00), COPD (0.80, 0.69-0.94), total cancer (0.94, 0.88-0.99), lung cancer (0.75, 0.58-0.97), anxiety (0.85, 0.78-0.92), NAFLD (0.66, 0.56-0.77), and CKD (0.74, 0.69-0.80).ConclusionsHigher PDQS scores are linked to reduced mortality and chronic disease risk. PDQS is a practical tool for assessing diet quality in epidemiological research.</p>
8 Authors
- Selma Kronsteiner-Gicevic
- Alysha S. Thompson
- Reynalda Cordova
- Martina Gaggl
- Jayne V. Woodside
- Aedín Cassidy
- Sabine Rohrmann
- Tilman Kühn
Enabling scientific discoveries that improve human health