| Title: | Cardiovascular health assessed by Life's Essential 8 score, genetic risk, colonoscopy status, and risk of colorectal cancer: an analysis of UK Biobank |
| Journal: | BMJ Open Gastroenterology |
| Published: | 18 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41850722/ |
| DOI: | https://doi.org/10.1136/bmjgast-2025-002010 |
| URL: | http://dx.doi.org/10.1136/bmjgast-2025-002010 |
Publication 17345
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Abstract
OBJECTIVE: Colorectal cancer (CRC) and cardiovascular disease (CVD) share common risk factors. This study explores the association between cardiovascular health (CVH), assessed using the Life's Essential 8 (LE8) score, and CRC risk, while examining the modifying roles of genetic predisposition and colonoscopy screening.</p>
METHODS: A total of 291 177 UK Biobank participants were included in the analysis. LE8 comprises eight indicators: diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. Cox proportional hazards models were used for analysis.</p>
RESULTS: During a median follow-up of 12.97 years, 3791 incident CRC cases were identified. Compared with low LE8 scores, high LE8 scores were associated with a 26% reduced CRC risk (HR: 0.74; 95% CI 0.64 to 0.86). High LE8 was linked to a 27% lower CRC risk in individuals with high genetic risk (HR: 0.73; 95% CI 0.56 to 0.94) and a 35% reduction in those without a history of colonoscopy screening (HR: 0.65; 95% CI 0.54 to 0.78). Joint analysis showed a 78% lower CRC risk in those with high LE8 and low genetic risk (HR: 0.22; 95% CI 0.15 to 0.34).</p>
CONCLUSION: Better CVH is associated with a reduced risk of CRC, particularly in individuals with high genetic susceptibility and those without a history of colonoscopy screening.</p>
22 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Body Mass Index
- Cardiovascular Diseases
- Colonoscopy
- Colorectal Neoplasms
- Early Detection of Cancer
- Exercise
- Female
- Follow-Up Studies
- Genetic Predisposition to Disease
- Genetic Risk Score
- Humans
- Incidence
- Male
- Middle Aged
- Proportional Hazards Models
- Risk Assessment
- Risk Factors
- UK Biobank
- United Kingdom
8 Authors
- Chengmiao Qiu
- Mengyang Wang
- Shujuan Lin
- Yang Zhong
- Miaomiao Fan
- Hao Chen
- Liyong Chen
- Hao Bai
1 Application
| Application ID | Title |
|---|---|
| 95817 | Sleep health and modifiable lifestyle factors in relation to gastrointestinal disease incidence and mortality |
Enabling scientific discoveries that improve human health