| Title: | Sleep disorders and sleep behaviors as predictors of neurodegenerative diseases |
| Journal: | Alzheimer's & Dementia |
| Published: | 18 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41851049/ |
| DOI: | https://doi.org/10.1002/alz.71301 |
Publication 17344
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Abstract
INTRODUCTION: The impact of sleep disorders (SDs) on incident neurodegenerative disease (NDD) risk has not been comprehensively investigated.</p>
METHODS: In the UK Biobank cohort, 30,032 participants with SDs (defined by diagnostic codes) and 147,321 without SDs were included. Cox proportional hazards models assessed associations between SDs and NDD risk. NDD prediction models incorporating SD subtype variables were developed.</p>
RESULTS: SD was associated with increased NDD risk (hazard ratio [HR]: 1.32, 95% confidence interval: 1.23 to 1.41). This association was observed regardless of treatment status, and several SD subtypes were also associated with increased NDD risk. Sleep behaviors, including difficulty waking and usual daytime napping, were associated with higher NDD risk among individuals with SD. SD subtype variables improved NDD prediction model performance and clinical utility in an external cohort.</p>
DISCUSSION: SDs and related sleep behaviors were strong predictors of NDD risk, underscoring their potential as targets for early prevention strategies.</p>
11 Keywords
- Aged
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Neurodegenerative Diseases
- Proportional Hazards Models
- Risk Factors
- Sleep Wake Disorders
- United Kingdom
8 Authors
- Taewon Kim
- Daeun Jung
- Kyung Min Kim
- Sanghyuk Lee
- Jungyon Yum
- Woo Seob Sim
- Phil Hyu Lee
- Yu Rang Park
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