| Title: | Plasma proteomic trajectories before the onset of neurodegenerative diseases |
| Journal: | Neurodegenerative Disease Management |
| Published: | 19 Mar 2026 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41858070/ |
| DOI: | https://doi.org/10.1080/17582024.2026.2646760 |
Publication 17341
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Abstract
BACKGROUND: The study aimed to identify indicative proteins associated with the occurrence and mortality of three neurodegenerative diseases (NDDs) and track the changes of proteins before the onset of NDDs.</p>
RESEARCH DESIGN AND METHODS: We analyzed plasma proteomic data from UK Biobank. Cox regression analyses were utilized to detect the relationship between plasma proteins and the risk of development and all-cause mortality of Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). Predictive models were established based on related proteins using Lasso regression.</p>
RESULTS: We identified 14 disease-associated proteins for AD, 35 for PD, and one for ALS. The trajectory of plasma proteins before the onset of NDDs was portrayed. Neuroinflammation and the remodeling of the extracellular matrix might be common pathways for NDDs.</p>
CONCLUSIONS: Our results highlighted that the landscape of plasma protein changes before the onset of NDDs.</p>
9 Authors
- Zhihan Zhang
- Rui Fan
- Sisi Jing
- Shiyi Liu
- Linqi Liu
- Wenjun Que
- Dan Lu
- Yaoqi Gan
- Fei Xiao
1 Application
| Application ID | Title |
|---|---|
| 103677 | Identification of epidemiological, genetic and clinical risk factors for the development of neuroimmune diseases and epilepsy. |
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