| Title: | Metabolic signature of EAT-Lancet diet in relation to risk of frailty: a prospective cohort study |
| Journal: | npj Science of Food |
| Published: | 26 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41298498/ |
| DOI: | https://doi.org/10.1038/s41538-025-00619-0 |
| URL: | https://www.nature.com/articles/s41538-025-00619-0.pdf |
Publication 17301
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Abstract
The EAT-Lancet Commission proposed a planetary health diet in 2019, yet its association with frailty remains unclear. This study aimed to examine the relationships between adherence to the EAT-Lancet diet, metabolomic profiles, and frailty risk among older adults. We included 44,465 participants from the UK Biobank, with a mean age of 55.88 years. Frailty was defined based on five physical criteria. Elastic net regression identified a 20-metabolite signature associated with the EAT-Lancet diet. Cox models showed that higher diet adherence was significantly associated with reduced frailty risk (HR: 0.51, 95% CI: 0.40 to 0.64). Each standard deviation increase in the metabolic signature was also associated with lower frailty risk (HR: 0.69, 95% CI: 0.63 to 0.75). Mediation analysis indicated that metabolites mediated 9.88% of the diet-frailty association. These findings suggest that greater adherence to the EAT-Lancet diet may lower frailty risk, partly mediated through specific metabolic pathways.</p>
7 Authors
- Jing Guo
- Guangning Kou
- Yongjian Zhu
- Rui Liang
- Hua Ye
- Xiangying Suo
- Yacong Bo
1 Application
| Application ID | Title |
|---|---|
| 93398 | Investigating the risk factors of non-communicable chronic disease using biomarkers, lifestyle factors, and environmental factors |
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