| Title: | Association of lifestyle and air pollution levels with psychiatric disorders: Findings from the UK Biobank |
| Journal: | Journal of Affective Disorders |
| Published: | 26 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41314551/ |
| DOI: | https://doi.org/10.1016/j.jad.2025.120773 |
Publication 17296
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Abstract
BACKGROUND: Extensive evidence indicates that lifestyle and air pollution levels are strongly associated with psychiatric disorders. However, few studies in this field have integrated these two factors to examine their relationship with psychiatric disorders.</p>
METHODS: In the primary UK Biobank cohort (n = 272,096), Cox proportional hazards models were employed to investigate the longitudinal associations between lifestyle, air pollution levels, and the risk of psychiatric disorders, adjusting for potential confounders. Additionally, three sub-cohorts (n = 280,087, 291,573, 301,933) were utilized to analyze the associations between lifestyle, air pollution levels, and specific psychiatric disorders, including depression, anxiety, and bipolar disorder. Interaction effects of lifestyle and air pollution levels were assessed.</p>
RESULTS: In the primary UK Biobank cohort, compared with participants maintaining a healthy lifestyle, those with a general lifestyle (Hazard ratio (HR) (95 %CI): 1.235(1.198, 1.273)) and those with an unhealthy lifestyle (HR (95 %CI): 1.634(1.545, 1.728)) had a significantly increased risk of any psychiatric disorder. Similarly, compared with participants in low air pollution environments, those in general air pollution environments (HR (95 %CI): 1.040 (1.003, 1.079)) and high air pollution environments (HR (95 %CI): 1.121 (1.080, 1.164)) also exhibited a significantly elevated risk of any psychiatric disorder. Furthermore, when both factors were present, individuals with general lifestyle and general air pollution exposure (Relative excess risk due to interaction (RERI) (95 %CI):0.087 (0.005, 0.170)), as well as those with unhealthy lifestyle and high air pollution exposure (RERI (95 %CI):0.231 (0.012, 0.450)), demonstrated an even greater risk of any psychiatric disorder.</p>
CONCLUSIONS: Unhealthy lifestyles and high air pollution generally increase the incidence of psychiatric disorders. Additionally, lifestyle and air pollution levels have an additive interaction effect on the risk of psychiatric disorders.</p>
17 Keywords
- Adult
- Aged
- Air Pollution
- Biological Specimen Banks
- Bipolar Disorder
- Cohort Studies
- Female
- Humans
- Life Style
- Longitudinal Studies
- Male
- Mental Disorders
- Middle Aged
- Proportional Hazards Models
- Risk Factors
- UK Biobank
- United Kingdom
12 Authors
- Mengyao Gao
- Shuting Ding
- Na Sun
- Weiqiang Su
- Chenyu Ma
- Minghao Wu
- Xue Di
- Xin Zhang
- Jiani Pan
- Fuyan Shi
- Suzhen Wang
- Yujia Kong
1 Application
| Application ID | Title |
|---|---|
| 78500 | Exploring the specific risk factors and key biomarkers for stroke using biochemical indicators, lifestyle, environmental factors and genetic information |
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