| Title: | Differential associations of cardiometabolic risk factors with liver-related events by alcohol consumption category: Results from a large population-based study. |
| Journal: | Hepatology |
| Published: | 26 Nov 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41295565/ |
| DOI: | https://doi.org/10.1097/hep.0000000000001628 |
Publication 17295
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND AND AIMS: The relative contributions of alcohol-associated and cardiometabolic drivers to liver-related events (LREs) remain unknown. We aimed to evaluate their relative contributions to LREs and examine possible interactions.</p>
APPROACH AND RESULTS: A total of 329,526 UK Biobank participants were included. Alcohol consumption was self-reported and categorized by weekly consumption as low (<140 g for females, <210 g for males), intermediate (140-350 g for females, 210-420 g for males), and high (>350 g for females, >420 g for males). Five cardiometabolic risk factors (CMRFs) were identified using diagnostic criteria for metabolic dysfunction-associated steatotic liver disease. Over a median follow-up of 12.8 years, 1809 LREs were documented. Alcohol consumption showed the strongest association with LREs. Among participants with low alcohol intake, pre-diabetes/diabetes (HR: 1.87, 95% CI: 1.64-2.14), low HDL cholesterol (1.79, 1.53-2.10), overweight/obesity (1.68, 1.40-2.01), hypertension (1.27, 1.06-1.53), and overall CMRF burden (5.61, 3.66-8.62) were associated with increased risk of LREs. The corresponding values for intermediate alcohol consumption were 2.00 (1.64-2.43), 1.47 (1.16-1.86), 1.19 (0.92-1.54), 1.90 (1.36-2.64), 5.95 (2.84-12.45); and for high consumption, 1.48 (1.17-1.87), 1.47 (1.11-1.95), 0.88 (0.66-1.18), 1.30 (0.88-1.94), 1.17 (0.58-2.34), respectively. A multiplicative interaction was observed between high alcohol consumption and CMRFs, but not between intermediate consumption and CMRFs.</p>
CONCLUSIONS: Excessive alcohol use appears to be the strongest factor associated with LREs. Associations between CMRFs and LREs seem similar among individuals with low and intermediate alcohol intake. Reducing alcohol intake, alongside targeted management of CMRFs, may improve strategies for preventing severe liver disease.</p>
10 Authors
- Hongliang Xue
- Liqing Wang
- Yuankai Wu
- Yingxin Liao
- Shijia Wang
- Ailan Chen
- Sun On Chan
- Wenhua Ling
- Xu Chen
- Chao Yu
2 Applications
| Application ID | Title |
|---|---|
| 76670 | Nutritional and lifestyle influences on the risk and outcome of different metabolic dysfunction-associated fatty liver disease (MAFLD) subtypes |
| 420999 | Dissecting the environmental, genetic and clinical determinants and their interactions on chronic diseases and its underlying mechanisms |
Enabling scientific discoveries that improve human health