| Title: | A sex-adjusted 7-biomarker clinical aging clock for translational preventative medicine |
| Journal: | Scientific Reports |
| Published: | 10 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41372266/ |
| DOI: | https://doi.org/10.1038/s41598-025-27478-9 |
| URL: | https://www.nature.com/articles/s41598-025-27478-9.pdf |
Publication 17253
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Abstract
Biological aging clocks capture heterogeneous rates of aging in individuals and transform current medical practice toward translational preventive medicine. Here, we developed a clinical aging clock based on routine blood biochemistry markers from 59,741 healthy samples in a Southeast Asian cohort. We established a novel correction method to address the systematic skew in predictions from first-generation clocks. This correction improved the accuracy of age-acceleration predictions for disease risks and enhanced interpretability for disease-driven and organ-specific aging processes without relying on mortality data. Based on only seven biomarkers, our clock accurately predicts both self-reported and physician-annotated ICD health data, indicating an increased hazard ratio. Importantly, the clock is robust even in the presence of acute infections or transient immune activation. To demonstrate the multi-ethnic generalizability of our biological age clock, we validated our approach using data from both the NHANES and UK Biobank cohorts. Our approach demonstrates the feasibility of a simple, robust, and interpretable clinical aging clock with potential for real-world implementation in personalized health monitoring and preventive care.</p>
14 Keywords
- Adult
- Aged
- Aged, 80 and over
- Aging
- Biological Clocks
- Biomarkers
- Cohort Studies
- Female
- Humans
- Male
- Middle Aged
- Preventive Medicine
- Sex Factors
- Translational Research, Biomedical
8 Authors
- David H. Meyer
- Gabriel Mejia
- Adrian Molière
- Panupong Wangprapa
- Tanawat Khunlertkit
- Polakit Teekakirikul
- Collin Y. Ewald
- Claudio Viecelli
Enabling scientific discoveries that improve human health