| Title: | Metabolic dysfunction-associated steatotic liver disease and the longitudinal progression of atrial fibrillation: a prospective study |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 25 Jul 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/40885642/ |
| DOI: | https://doi.org/10.1016/j.numecd.2025.104266 |
Publication 17221
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Abstract
BACKGROUND AND AIM: Atrial fibrillation (AF) frequently coexists with other complications, including myocardial infarction (MI), heart failure (HF), stroke, and dementia. The contribution of metabolic dysfunction-associated steatotic liver disease (MASLD) to the development and mortality of AF was under-recognized. This study aims to investigate the impact of MASLD on the progression of AF and the mediating effect of carotid intima-media thickness (cIMT).</p>
METHODS AND RESULTS: Multistate analysis was conducted to investigate the associations of MASLD with the progression from health to AF, further AF-related complications, and ultimately death. Counterfactual mediation analysis was employed to quantify the extent to which cIMT explained the associations of MASLD with AF, AF-related complications, and death. As many as 350,745 participants were followed for a median of 13.67 (IQR = 12.94 to 14.38) years. Among them, 21,240 (6.06 %) participants experienced AF, 5,808 (27.34 %) developed AF-related complications, afterwards, 1,854 (31.92 %) were died. Compared with non-MASLD, MASLD patients exhibited a higher risk of transitions from health to AF, then to AF-related complications, particularly transition from health to AF, with HR was 1.52 (95 % CI: 1.48-1.57). The proportion mediated by cIMT for AF, AF-related complications, and mortality were 16.51 %, 18.06 %, and 15.14 %, respectively.</p>
CONCLUSIONS: Our study revealed that MASLD heightened the risk of the longitudinal advancement of AF, with cIMT recognized as a crucial mediator. This highlights the significance of managing MASLD patients and monitoring atherosclerosis for the subclinical prevention of AF progression.</p>
10 Authors
- Yali Niu
- Tianrun Wang
- Xiaocan Jia
- Zhixing Fan
- Chaojun Yang
- Yuping Wang
- Jingwen Fan
- Chenyu Zhao
- Nana Wang
- Xuezhong Shi
1 Application
| Application ID | Title |
|---|---|
| 170605 | Association analysis, causal inference, and modeling of genetic, environmental, lifestyle, and clinical determinants in the occurrence, progression, and prognosis of age-related diseases |
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