| Title: | EAT-Lancet and plant-based diets, plasma metabolomic signatures, and biological aging |
| Journal: | npj Aging |
| Published: | 12 Dec 2025 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/41388028/ |
| DOI: | https://doi.org/10.1038/s41514-025-00306-0 |
| URL: | https://www.nature.com/articles/s41514-025-00306-0_reference.pdf |
Publication 17196
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
The EAT-Lancet diet has been recently recommended for its potential health and environmental benefits. Here, leveraging data from the UK Biobank, we performed a comparative analysis to examine the associations of adherence to the EAT-Lancet diet versus traditional plant-based diets with biological aging and further assess the mediating role of metabolomic signatures specific to dietary patterns. Compared with the overall or healthful plant-based diet index, higher adherence to the EAT-Lancet diet was more strongly associated with decreased KDM-BA and PhenoAge acceleration and increased telomere length. In contrast, a higher unhealthful plant-based diet index was associated with accelerated biological aging. We identified substantial metabolomic variation in relation to different dietary patterns. The diet-specific metabolomic signatures mediated 26.9-63.0% of the associations between dietary patterns and biological aging. Our findings suggest the potential benefits of adopting the EAT-Lancet and plant-based diets in promoting healthy aging and highlight the potential of metabolomic signatures for informing personalized nutrition interventions.</p>
8 Authors
- Jie Li
- Jiang Li
- Xiaoqin Xu
- Kun Zhang
- Ningjian Wang
- Lu Qi
- Bin Wang
- Yingli Lu
1 Application
| Application ID | Title |
|---|---|
| 77740 | Environmental factors in adulthood, genetic predisposition, and human common diseases |
Enabling scientific discoveries that improve human health