| Title: | Risk Factors and Disease Prediction for Cognitive Function, Brain Structure, Cardiovascular and Neurodegenerative Diseases, and Metabolic Disorders |
| Lead Institution: | Jilin University |
| Principal investigator: |
Application 710075
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About
Research Outline: Risk Factor Analysis and Disease Prediction Research Questions 1.Explore the common and unique risk factors for cognitive decline, brain structural changes, cardiovascular disease, neurodegenerative disorders, and metabolic diseases.2.Investigate the interactions between these risk factors.3.Development of disease prediction models.4.Potential therapeutic targets or preventive strategies. Research Objectives 1.Investigate the factors influencing brain health and cardiovascular diseases.2.Examine the impact of risk factors for one disease on the risk of another disease.3.Develop models to predict disease risk and progression.4.ropose strategies to mitigate the risk of cognitive decline and related diseases Scientific Basis 1.Genetics: Genetic factors play a crucial role in the diagnosis, prognosis, and treatment of brain health disorders and cardiovascular diseases, influencing disease progression. 2.Lifestyle: Behaviors such as diet, sleep patterns, smoking, and alcohol consumption are key determinants of risk for these disease categories, affecting inflammatory processes, vascular health, and metabolic functions. 3.Biomarkers: Inflammatory markers and glucose levels provide valuable insights into the pathophysiology and progression of cardiovascular and neurodegenerative diseases, aiding in early detection and monitoring. 4.Neuroimaging: Advanced neuroimaging techniques, including MRI and PET scans, enable the detection of structural and functional changes in the brain, which are critical for understanding the impact of cardiovascular diseases on brain health.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18984 | Association between Accelerometer-derived Physical Activity-related Metabolic Signature and Stroke: A Cohort Study from UK Biobank | Bowen Tan (+11) | 2025 | The journal of nutrition health & aging |
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