| Title: | Heterogeneity of Chronic Liver Disease |
| Lead Institution: | University of Helsinki |
| Principal investigator: | Dr Panu Luukkonen |
Application 62797
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About
Chronic liver diseases, such as alcoholic and non-alcoholic fatty liver disease, encompass a continuum ranging from steatosis to cirrhosis and liver cancer and affect up to 1 in 4 people world-wide. For unclear reasons, only a small portion of individuals develop the most severe forms of chronic liver disease. We aim to identify genetic and non-genetic risk factors and their interaction to elucidate the susceptibility to advanced liver disease. Moreover, we aim to develop tools for the use of doctors to better identify individuals who are at a particularly high risk of advanced liver disease. Better understanding of the modifiable risk factors could also inform of potential treatment targets. Duration: 36 months.5 Publications
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 9142 | Combined use of the CLivD score and FIB-4 for prediction of liver-related outcomes in the population | Fredrik Åberg (+3) | 2023 | Hepatology |
| 15542 | Evidence-based criteria for identifying at-risk individuals requiring liver disease screening | Fredrik Åberg (+8) | 2025 | Hepatology Communications |
| 10155 | Protein Phosphatase 1 Regulatory Subunit 3 Beta rs4240624 Genotype Is Associated With Gallstones and With Significant Changes in Bile Lipidome | Ville T. Männistö (+13) | 2024 | Gastro Hep Advances |
| 15791 | Risk stratification beyond fibrosis in SLD: The case for lifestyle-responsive prognostic tools | Fredrik Åberg (+2) | 2025 | Journal of Hepatology |
| 19378 | Use of new CORE risk score to predict 10 year risk of liver cirrhosis in general population: population based cohort study | Rickard Strandberg (+11) | 2025 | The BMJ |
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