| Title: | Untangling the role of Schwann cells in chronic pain |
| Lead Institution: | University of Florence |
| Principal investigator: |
Application 501518
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About
This project aims to dissect the role of Schwann cells in chronic pain using the extensive data available from the UK Biobank database. Objectives To identify genetic variants associated with Schwann cell function that correlate with chronic pain in the UK Biobank cohort. To investigate the relationship between Schwann cell dysfunction, nerve damage, and chronic pain. To explore how Schwann cell-related biomarkers could predict or modulate chronic pain states. Methodology Data Extraction: Utilize data from the UK Biobank, including genetic data, clinical records, imaging, and pain assessments. Genetic Analysis: Perform genome-wide association studies (GWAS) to identify genetic variants associated with Schwann cell function and chronic pain. Bioinformatics and Computational Modeling: Analyze gene expression patterns, epigenetic modifications, and molecular pathways involved in Schwann cell function and chronic pain. Statistical Analysis: Use advanced statistical methods to correlate genetic and phenotypic data, focusing on variables related to chronic pain outcomes. Expected Outcomes Identification of key genetic and molecular factors linking Schwann cells to chronic pain. Development of potential biomarkers for predicting susceptibility to chronic pain. Insights into new therapeutic targets for pain management focused on Schwann cell pathways. Significance and Impact This research will provide novel insights into the biological underpinnings of chronic pain, potentially leading to innovative approaches for diagnosis, prevention, and treatment. By leveraging the UK Biobank's resources, the study aims to make substantial contributions to understanding the role of Schwann cells in pain modulation and improve patient outcomes.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18537 | Subcortical neuroimaging signature of painful disorders of the trigeminal nerve: a UK Biobank study | Marcos Fabio Henriques DosSantos (+6) | 2026 | The Journal of Headache and Pain |
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