| Title: | Life's Essential 8 and risk of cancer incidence and mortality |
| Lead Institution: | Second Hospital of Jilin University |
| Principal investigator: |
Application 430579
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About
Cancer is main leading cause of death and an important barrier to increasing life expectancy in the most of countries worldwide. Globally, cancer incidence and mortality are rapidly growing, however, the reasons are complex, which involves socio-economic development, population aging and growth, as well as changes in environmental and modifiable lifestyle factors. Previous studies have shown that individuals with a higher cardiovascular health level may associated with a lower risk of cancer, as well as risk of all-cause mortality. However, most of the studies quantifies their single impact on the cancer incidence and mortality without searching for possible combined and synergic effects among other modifiable lifestyle, biochemical, and environmental factors. Using the data already collected in UK Biobank, we aim to assess the associations of cardiovascular health, assessed by the American Heart Association's Life's Essential 8, and incidence and mortality of cancers in the UK population, and investigated the combined and synergistic effects of Life's Essential 8 and genetic risk on incidence and mortality of cancers. The estimated duration of this project is 36 months. This project is expected to improve understanding of the impact of cardiovascular health and genetic risk on the cancer incidence and mortality and therefore contribute to developing prevention and intervention strategies.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 17299 | Association between multimarkers of metabolic malnutrition and inflammation and risk of chronic obstructive pulmonary disease and lung function: a prospective cohort study of UK biobank | Chengyan Jin (+4) | 2025 | Nutrition & Metabolism |
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