| Title: | The impact of lifestyle, environment, genotype, and nutritional metabolic health on the occurrence, development, and prognosis of cardiovascular disease |
| Lead Institution: | Beijing Friendship Hospital, Capital Medical University |
| Principal investigator: |
Application 335191
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About
The incidence and mortality rates of cardiovascular diseases (CVD) are steadily increasing worldwide, leading to a decline in patients' quality of life and a growing socioeconomic burden. In terms of public health, research on detecting risk factors remains crucial, as identifying high-risk factors for cardiovascular diseases is essential for early prevention and detection. While past studies have highlighted the effects of lifestyle, genetics, and nutritional health factors on certain cardiovascular diseases, the interactions among these factors and their biological mechanisms require further evaluation. This study aims to delve deeply into the complex interactions among lifestyle, environment, genetics, and nutritional metabolic health factors to comprehensively understand their impact on the occurrence, progression, and prognosis of cardiovascular diseases. The project is planned to extend over 36 months, with a focus on utilizing the complete dataset of the UK Biobank. Through Mendelian randomization and multi-gene risk score analysis, the study will investigate the effects of genetic variations on cardiovascular diseases. By constructing multivariable adjustment models, Cox proportional hazards models, mixed-effect models, interaction analysis, and multivariable trajectory analysis, the study will explore the impact of changeable environmental, genetic, metabolic, dietary, and lifestyle interactions on the occurrence, development, and prognosis of specific cardiovascular diseases. This study will contribute to understanding how the interactions between lifestyle, environment, genetics, and nutritional metabolic health impact the onset, progression, and prognosis of cardiovascular diseases. Furthermore, it will provide more effective preventive and risk stratification strategies for patients with cardiovascular diseases, as well as scientific foundations for the development of targeted intervention approaches.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18234 | Asthma and cardiovascular outcomes: a population-based matched cohort study | Cheng Yang (+7) | 2026 | European Journal of Preventive Cardiology |
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