| Title: | Clonal hematopoiesis in the development of EBV-related lymphomas. |
| Lead Institution: | The Second Affiliated Hospital of Nanchang University |
| Principal investigator: |
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About
EBV (Epstein-Barr virus) belongs to the herpesvirus family, and nearly 95% of the population will become infected during their lifetime. Although EBV is generally considered a harmless latent virus for most individuals, its reactivation can lead to serious health issues such as lymphoma. The positive rate of EBV is approximately 15% to 30% in patients with lymphoma, though the underlying mechanisms remain unclear. Clone hematopoiesis (CH) represents an expanded somatic cell clone present in individuals without other hematologic abnormalities, and only 0.5% to 1% of CH cases progress to hematologic malignancies annually. To delve deeper into the pathogenesis of EBV-associated lymphomas, we conducted targeted sequencing on 99 cases of EBV-positive lymphomas and uncovered a notable frequency of mutations in CH genes, suggesting a potentially significant role for CH in the development of EBV-related lymphomas. Moreover, previous studies have reported that TET2 and DNMT3A-mediated CH was detected in 60-70% of lymphomas, which is consistent with our findings. Therefore, we propose a scientific hypothesis: CH genes may serve as catalysts, propelling the transformation of EBV-infected individuals towards lymphoma. Our project aims to explore the relationship between CH and EBV-related lymphomas, as well as potential risk factors for CH progression to EBV-related lymphomas. We plan to collect relevant data from the UK Biobank database and analyze it over a period of 36 months. Our research findings may provide important insights for more accurate prediction and better management of EBV-related lymphomas in the future.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18318 | Associations of serum lipid traits with DLBCL: a prospective cohort study from the UK Biobank | QingQing Luo (+4) | 2026 | Frontiers in Nutrition |
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