| Title: | Exploring the Correlation Between Metabolic Diseases and Neurological Disorders and the Underlying Neuroendocrine Mechanisms |
| Lead Institution: | Ningxia Medical University |
| Principal investigator: |
Application 278107
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About
Our research project aims to explore the connection between metabolic diseases, such as diabetes and obesity, and neurological disorders, including Alzheimer's disease and Parkinson's disease. We want to understand how these seemingly different health issues might be related and what underlying mechanisms, particularly in the neuroendocrine system, might explain their connection. The scientific rationale behind our study is based on the observation that metabolic diseases can have a significant impact on the brain's health. For example, high blood sugar levels in diabetes can damage blood vessels in the brain, leading to cognitive decline or even stroke. Additionally, hormones that regulate metabolism, like insulin, also play a role in brain function. Therefore, we suspect that disturbances in these hormonal pathways might link metabolic diseases to neurological disorders. To investigate this, we will use data from the UK Biobank, a large database that contains genetic information, health records, and even brain imaging data from over 500,000 individuals. By analyzing this data, we hope to identify genetic markers and patterns in brain imaging that are common to both metabolic and neurological diseases. This will help us understand whether there is a direct link between the two and what biological mechanisms might be involved. Our project is expected to last for three years. During this time, we will conduct a detailed analysis of the UK Biobank data, focusing on identifying any shared genetic factors and brain imaging features between metabolic and neurological diseases. The public health impact of our research could be significant. If we can better understand the connection between metabolic and neurological diseases, we might be able to develop new strategies for prevention and treatment. For example, early interventions to manage metabolic health could potentially reduce the risk of developing neurological disorders later in life. Additionally, our findings could lead to the discovery of new biomarkers for early detection of these diseases, improving patient outcomes. Overall, this research has the potential to contribute to a more integrated approach to managing metabolic and neurological health, ultimately improving the quality of life for individuals affected by these conditions.1 Publication
| Pub ID | Title | Author(s) | Year | Journal |
|---|---|---|---|---|
| 18935 | Genetic homocysteine risk shapes cardiocerebral structure and multimorbidity through age- and sex-specific mechanisms: a UK Biobank study | Chenjie Feng (+4) | 2025 | Frontiers in Nutrition |
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